| The neurobiology of social phobia. | |
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MedLine Citation:
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PMID: 8923109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in the neurobiology of social phobia have used neuroendocrine, naturalistic and chemical challenges, pharmacological probes, neurotransmitter system measures, peripheral receptor binding and magnetic resonance measures. Studies of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axes have been largely unrevealing; adrenaline, carbon dioxide, caffeine and yohimbine tests have provided mixed results; probe studies using L-dopa, clonidine and fenfluramine have provided some evidence of post-synaptic serotonergic abnormality; studies on platelet and lymphocyte binding have failed to distinguish social phobia from other groups; magnetic resonance imaging and magnetic resonance spectroscopy studies suggest possible differences between patients with social phobia and healthy controls in respect of dopamine, serotonin and second-messenger function. In aggregate, these studies have provided some neurobiological basis for separating social phobia from panic disorder and non-psychiatric healthy controls. |
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Authors:
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N L Potts; S Book; J R Davidson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: International clinical psychopharmacology Volume: 11 Suppl 3 ISSN: 0268-1315 ISO Abbreviation: Int Clin Psychopharmacol Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1997-03-12 Completed Date: 1997-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8609061 Medline TA: Int Clin Psychopharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology Diagnosis, Differential Humans Magnetic Resonance Imaging Neurosecretory Systems / physiopathology Neurotransmitter Agents / physiology Panic Disorder / diagnosis Phobic Disorders / diagnosis*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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