| The neurobiology of opioid dependence: implications for treatment. | |
| | |
MedLine Citation:
|
PMID: 18567959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser's struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments. |
| | |
Authors:
|
Thomas R Kosten; Tony P George |
Related Documents
:
|
23764209 - Frailty consensus: a call to action. 21049779 - Medication reconciliation: another change planned. 3327439 - Zinc protoporphyrin. past, present, and future. 2654039 - A review of the evidence concerning the impact of medical measures on recent mortality ... 17485739 - Balancing modern medical benefits and risks. 11420869 - Commitment to change statements: a way of understanding how participants use informatio... 16501279 - Medical students' involvement in outpatient clinical encounters: a survey of patients a... 2588589 - Diagnostic patterns in hospital use by an urban homeless population. 11533999 - The raymond pearl memorial lecture, 1997: the quest for medical normalcy-who needs it? |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Science & practice perspectives / a publication of the National Institute on Drug Abuse, National Institutes of Health Volume: 1 ISSN: 1930-4307 ISO Abbreviation: Sci Pract Perspect Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2008-06-23 Completed Date: 2008-08-15 Revised Date: 2013-06-05 |
Medline Journal Info:
|
Nlm Unique ID: 101275423 Medline TA: Sci Pract Perspect Country: United States |
Other Details:
|
Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
|
Yale University School of Medicine, New Haven, Connecticut, USA. thomas.kosten@yale.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesics, Opioid
/
pharmacology,
therapeutic use Behavior, Addictive / physiopathology Brain / metabolism, physiopathology* Humans Models, Neurological Narcotic Antagonists / pharmacology, therapeutic use Opioid-Related Disorders / physiopathology*, rehabilitation Receptors, Opioid / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
K05-DA-0-0454/DA/NIDA NIH HHS; K12-DA-0-0167/DA/NIDA NIH HHS; P50-DA-1-2762/DA/NIDA NIH HHS; R01-DA-1-3672/DA/NIDA NIH HHS; R01-DA-1-4039/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 0/Narcotic Antagonists; 0/Receptors, Opioid |
| Comments/Corrections | |
Comment In:
|
Sci Pract Perspect. 2002 Jul;1(1):21
[PMID:
18567960
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HIV/hepatitis prevention in drug abuse treatment programs: guidance from research.
Next Document: Treatment practice and research issues in improving opioid treatment outcomes.