Document Detail


The neurobiology of infant maternal odor learning.
MedLine Citation:
PMID:  20835686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infant rats must learn to identify their mother's diet-dependent odor. Once learned, maternal odor controls pups' approach to the mother, their social behavior and nipple attachment. Here we present a review of the research from four different laboratories, which suggests that neural and behavioral responses to the natural maternal odor and neonatal learned odors are similar. Together, these data indicate that pups have a unique learning circuit relying on the olfactory bulb for neural plasticity and on the hyperfunctioning noradrenergic locus coeruleus flooding the olfactory bulb with norepinephrine to support the neural changes. Another important factor making this system unique is the inability of the amygdala to become incorporated into the infant learning circuit. Thus, infant rats appear to be primed in early life to learn odors that will evoke approach responses supporting attachment to the caregiver.
Authors:
C Raineki; A Pickenhagen; T L Roth; D M Babstock; J H McLean; C W Harley; A B Lucion; R M Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-09-10
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  43     ISSN:  1414-431X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2011-05-04     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  914-9     Citation Subset:  IM    
Affiliation:
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. craineki@nki.rfmh.org
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MeSH Terms
Descriptor/Qualifier:
Amygdala / physiology*
Animals
Animals, Newborn
Cues*
Discrimination Learning / physiology*
Feeding Behavior / physiology*
Female
Locus Coeruleus / physiology*
Neuronal Plasticity / physiology
Norepinephrine / physiology
Odors*
Olfactory Bulb / physiology*
Rats
Grant Support
ID/Acronym/Agency:
DC009910/DC/NIDCD NIH HHS; MH091451/MH/NIMH NIH HHS; MOP53761//Canadian Institutes of Health Research; R01 DC009910/DC/NIDCD NIH HHS; R01 MH091451/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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