Document Detail

The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines.
MedLine Citation:
PMID:  20870295     Owner:  NLM     Status:  MEDLINE    
In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder, since recent data indicate a critical involvement of innate and adaptive immune responses following nerve injury. Activation of immune and immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
Paul J Austin; Gila Moalem-Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-25
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  229     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  26-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
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MeSH Terms
Cytokines / metabolism*
Immune System / physiopathology*
Inflammation / immunology,  pathology*
Nervous System / physiopathology*
Neuralgia* / immunology,  metabolism,  pathology
Neuroglia / immunology*,  metabolism
Reg. No./Substance:

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