Document Detail


The neural tube origin of ventral root sheath cells in the chick embryo.
MedLine Citation:
PMID:  3446475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The embryonic origin of peripheral nerve Schwann/sheath cells is still uncertain. Although the neural crest is known to be an important source, it is not clear whether the ventral neural tube also contributes a progenitor population for motor axons. We have used the techniques of immunohistochemistry, electron microscopy and quail-chick grafting to examine this problem. Immunohistochemistry with monoclonal antibody HNK-1 identified a cluster of immunoreactive cells in the sclerotome, at the site of the future ventral root. With the electron microscope, nucleated cells could not be seen breaching the basal lamina of the neural tube, exclusively in the region of the ventral root and preceding axon outgrowth. After grafting a length of crest-ablated quail neural tube in place of host chick neural tube, a population of quail cells was found localized to the ventral root exit zone, associated with the ventral root axons. Taken together, these observations support the possibility of a neural tube origin for ventral root sheath cells, although we found no evidence for a more extensive migration of these cells. The ventral root cells share certain phenotypic traits, such as HNK-1 immunoreactivity, with neural-crest-derived Schwann cells, but are not necessarily identical to them. We argue that while they may help motor axons to exit the neural tube at the correct position, they are unlikely to guide axons beyond the immediate vicinity of the neural tube.
Authors:
E R Lunn; J Scourfield; R J Keynes; C D Stern
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  101     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-05-24     Completed Date:  1988-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Chimera
Immunohistochemistry
Microscopy, Electron
Nervous System / embryology*,  ultrastructure
Quail
Schwann Cells / physiology*

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