Document Detail

The neural and humoral pathways in remote limb ischemic preconditioning.
MedLine Citation:
PMID:  20449597     Owner:  NLM     Status:  MEDLINE    
Remote ischaemic preconditioning (RIPC) is a therapeutic intervention that has been demonstrated to reduce myocardial injury in the clinical setting. However, the underlying cardioprotective mechanisms remain unclear. We hypothesised that RIPC utilises both humoral and neural pathways to convey the cardioprotective signal from the preconditioned remote organ to the heart. C57BL/6 mice were anaesthetised and subjected to in vivo 30 min coronary artery ischaemia followed by 120 min of myocardial reperfusion, at the end of which myocardial infarct size was measured and expressed as a percentage of the risk zone. RIPC was induced by 3 cycles of 5 min left femoral artery occlusion interspersed with 5 min reperfusion before prolonged myocardial ischaemia with or without femoral vein occlusion (humoral pathway), femoral nerve resection and/or sciatic nerve resection (neural pathway). RIPC resulted in a smaller myocardial infarct size when compared to control. However, occluding the femoral vein completely abolished the infarct-limiting effect of RIPC. Similarly, combined femoral and sciatic nerve resection also abolished the cardioprotective effect of RIPC. Interestingly, femoral nerve or sciatic nerve resection alone only partially abolished the infarct-limiting effect of RIPC. In conclusion, remote limb ischaemic preconditioning reduced myocardial infarct size in the mice in a manner which implicates both a neural and humoral pathway.
Shiang Y Lim; Derek M Yellon; Derek J Hausenloy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-07
Journal Detail:
Title:  Basic research in cardiology     Volume:  105     ISSN:  1435-1803     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-11-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  651-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Disease Models, Animal
Femoral Vein / innervation,  physiology*
Heart Rate / physiology
Hindlimb / blood supply,  innervation
Ischemic Preconditioning, Myocardial / methods*
Mice, Inbred C57BL
Myocardial Reperfusion Injury* / metabolism,  physiopathology,  prevention & control
Sciatic Nerve / blood supply,  physiology*
Signal Transduction / physiology*
Grant Support
RG/08/015/26411//British Heart Foundation; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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