| The neural and humoral pathways in remote limb ischemic preconditioning. | |
| | |
MedLine Citation:
|
PMID: 20449597 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Remote ischaemic preconditioning (RIPC) is a therapeutic intervention that has been demonstrated to reduce myocardial injury in the clinical setting. However, the underlying cardioprotective mechanisms remain unclear. We hypothesised that RIPC utilises both humoral and neural pathways to convey the cardioprotective signal from the preconditioned remote organ to the heart. C57BL/6 mice were anaesthetised and subjected to in vivo 30 min coronary artery ischaemia followed by 120 min of myocardial reperfusion, at the end of which myocardial infarct size was measured and expressed as a percentage of the risk zone. RIPC was induced by 3 cycles of 5 min left femoral artery occlusion interspersed with 5 min reperfusion before prolonged myocardial ischaemia with or without femoral vein occlusion (humoral pathway), femoral nerve resection and/or sciatic nerve resection (neural pathway). RIPC resulted in a smaller myocardial infarct size when compared to control. However, occluding the femoral vein completely abolished the infarct-limiting effect of RIPC. Similarly, combined femoral and sciatic nerve resection also abolished the cardioprotective effect of RIPC. Interestingly, femoral nerve or sciatic nerve resection alone only partially abolished the infarct-limiting effect of RIPC. In conclusion, remote limb ischaemic preconditioning reduced myocardial infarct size in the mice in a manner which implicates both a neural and humoral pathway. |
| | |
Authors:
|
Shiang Y Lim; Derek M Yellon; Derek J Hausenloy |
Related Documents
:
|
16288777 - The ubiquitous role of nitric oxide in cardioprotection. 10500207 - The late phase of ischemic preconditioning is abrogated by targeted disruption of the i... 1378687 - Cardioprotection by molsidomine and iloprost in myocardial ischemia in anaesthetized cats. 19691857 - Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells tran... 11049887 - Off-pump versus on-pump coronary artery bypass surgery and postoperative renal dysfunct... 21307037 - Relationship between risk stratification at admission and treatment effects of early in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-07 |
Journal Detail:
|
Title: Basic research in cardiology Volume: 105 ISSN: 1435-1803 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 651-5 Citation Subset: IM |
Affiliation:
|
The Hatter Cardiovascular Institute, University College London Hospital and Medical School, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Nursing concepts for patients with dementia. Systematic review].
Next Document: Total laparoscopic hysterectomy without uterine manipulator: description of a new technique and its ...