Document Detail


The neural correlates of intentional learning of verbal materials: a PET study in humans.
MedLine Citation:
PMID:  8957565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to identify the brain regions invoked when subjects attempt to learn verbal materials for a subsequent memory test. Twelve healthy subjects undertook two different tasks: reading and encoding of word pairs, while they were being scanned using [15O]H2O positron emission tomography (PET). As expected, the encoding pairs were remembered much better (recall 39% vs. 8%; P < 0.001) than reading pairs in a subsequent memory test. The encoding scans, as compared to reading scans, showed activation of the left prefrontal cortex, the anterior cingulate cortex and the left medial temporal cortex. The left prefrontal activations were in two discrete regions: (i) a left anterior and inferior left prefrontal (Brodmann's areas 45, 46) which we attribute to semantic processing; and (ii) a left posterior mid-frontal region (BA 6, 44) which may reflect rote rehearsal. We interpret the data to suggest that when subjects use cognitive strategies of semantic processing and rote-rehearsal to learn words, they invoke discrete regions of the left prefrontal cortex. And this activation of the left prefrontal cortex along with the medial temporal region leads to a neurophysiological memory trace which can be used to guide subsequent memory retrieval.
Authors:
S Kapur; E Tulving; R Cabeza; A R McIntosh; S Houle; F I Craik
Related Documents :
24917385 - Eavesdropping on heterospecific alarm calls: from mechanisms to consequences.
9714705 - Functional mri studies of spatial and nonspatial working memory.
19718655 - Executive function and error detection: the effect of motivation on cingulate and ventr...
16843445 - Temporal changes in neural activation during practice of information retrieval from sho...
23320735 - Representation of action in parkinson's disease: imagining, observing, and naming actions.
24149895 - Evolution of the techniques used in studying associative olfactory learning and memory ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Cognitive brain research     Volume:  4     ISSN:  0926-6410     ISO Abbreviation:  Brain Res Cogn Brain Res     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214304     Medline TA:  Brain Res Cogn Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  243-9     Citation Subset:  IM    
Affiliation:
PET Centre, Clake Institute of Psychiatry, Toronto, Ont., Canada, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiology*,  radionuclide imaging
Female
Humans
Language
Learning / physiology*
Male
Memory / physiology*
Tomography, Emission-Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Task-induced asymmetry of the auditory evoked M100 neuromagnetic field elicited by speech sounds.
Next Document:  An event-related potential study of word-stem cued recall.