Document Detail

The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome.
MedLine Citation:
PMID:  18447963     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little is known about its neural correlates. The aim of this study was to explore the functional brain response, using functional magnetic resonance imaging (fMRI), to the imaginal experience of fatigue in CFS patients and controls. METHOD: We compared the blood oxygen level dependent (BOLD) responses of 12 CFS patients and 11 healthy controls to a novel fatigue provocation procedure designed to mimic real-life situations. A non-fatiguing anxiety-provoking condition was also included to control for the non-specific effects of negative affect. RESULTS: During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. The reverse pattern of findings was observed during the anxiety-provoking scenarios. CONCLUSIONS: The results may suggest that, in CFS patients, the provocation of fatigue is associated with exaggerated emotional responses that patients may have difficulty suppressing. These findings are discussed in relation to the cognitive-behavioural model of CFS.
X Caseras; D Mataix-Cols; K A Rimes; V Giampietro; M Brammer; F Zelaya; T Chalder; E Godfrey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-30
Journal Detail:
Title:  Psychological medicine     Volume:  38     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-30     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  941-51     Citation Subset:  IM    
Unitat de Psicologia Mèdica, Institut de Neurociències, Universitat Autònoma de Barcelona, Catalonia, Spain.
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MeSH Terms
Case-Control Studies
Cerebellum / physiopathology
Cognitive Therapy*
Fatigue / physiopathology*
Fatigue Syndrome, Chronic / physiopathology*,  psychology
Magnetic Resonance Imaging / methods*
Middle Aged
Pilot Projects
Psychomotor Performance / physiology
Reaction Time
Visual Perception / physiology
Comment In:
Psychol Med. 2009 Mar;39(3):523-4   [PMID:  19091159 ]

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