Document Detail

A neural correlate of reward-based behavioral learning in caudate nucleus: a functional magnetic resonance imaging study of a stochastic decision task.
MedLine Citation:
PMID:  14973239     Owner:  NLM     Status:  MEDLINE    
Humans can acquire appropriate behaviors that maximize rewards on a trial-and-error basis. Recent electrophysiological and imaging studies have demonstrated that neural activity in the midbrain and ventral striatum encodes the error of reward prediction. However, it is yet to be examined whether the striatum is the main locus of reward-based behavioral learning. To address this, we conducted functional magnetic resonance imaging (fMRI) of a stochastic decision task involving monetary rewards, in which subjects had to learn behaviors involving different task difficulties that were controlled by probability. We performed a correlation analysis of fMRI data by using the explanatory variables derived from subject behaviors. We found that activity in the caudate nucleus was correlated with short-term reward and, furthermore, paralleled the magnitude of a subject's behavioral change during learning. In addition, we confirmed that this parallelism between learning and activity in the caudate nucleus is robustly maintained even when we vary task difficulty by controlling the probability. These findings suggest that the caudate nucleus is one of the main loci for reward-based behavioral learning.
Masahiko Haruno; Tomoe Kuroda; Kenji Doya; Keisuke Toyama; Minoru Kimura; Kazuyuki Samejima; Hiroshi Imamizu; Mitsuo Kawato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  24     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-05-04     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1660-5     Citation Subset:  IM    
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MeSH Terms
Behavior / physiology*
Brain Mapping
Caudate Nucleus / anatomy & histology,  physiology*
Decision Making / physiology*
Learning / physiology*
Magnetic Resonance Imaging
Stochastic Processes*
Task Performance and Analysis

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