Document Detail


A neural circuit for spatial summation in visual cortex.
MedLine Citation:
PMID:  23060193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the centre of its receptive field, a phenomenon called surround suppression. Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely relayed from earlier stages of visual processing is debated. Here we show that, in contrast to pyramidal cells, the response of somatostatin-expressing inhibitory neurons (SOMs) in the superficial layers of the mouse visual cortex increases with stimulation of the receptive-field surround. This difference results from the preferential excitation of SOMs by horizontal cortical axons. By perturbing the activity of SOMs, we show that these neurons contribute to pyramidal cells' surround suppression. These results establish a cortical circuit for surround suppression and attribute a particular function to a genetically defined type of inhibitory neuron.
Authors:
Hillel Adesnik; William Bruns; Hiroki Taniguchi; Z Josh Huang; Massimo Scanziani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  490     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2012-11-06     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  226-31     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, California 92093-0634, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism
Mice
Postsynaptic Potential Summation / physiology*
Pyramidal Cells / metabolism
Retinal Neurons / cytology,  physiology
Visual Cortex / physiology*
Grant Support
ID/Acronym/Agency:
NS069010/NS/NINDS NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Comments/Corrections

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