| A neural circuit for spatial summation in visual cortex. | |
| | |
MedLine Citation:
|
PMID: 23060193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the centre of its receptive field, a phenomenon called surround suppression. Whether cortical circuits contribute to surround suppression or whether the phenomenon is entirely relayed from earlier stages of visual processing is debated. Here we show that, in contrast to pyramidal cells, the response of somatostatin-expressing inhibitory neurons (SOMs) in the superficial layers of the mouse visual cortex increases with stimulation of the receptive-field surround. This difference results from the preferential excitation of SOMs by horizontal cortical axons. By perturbing the activity of SOMs, we show that these neurons contribute to pyramidal cells' surround suppression. These results establish a cortical circuit for surround suppression and attribute a particular function to a genetically defined type of inhibitory neuron. |
| | |
Authors:
|
Hillel Adesnik; William Bruns; Hiroki Taniguchi; Z Josh Huang; Massimo Scanziani |
Related Documents
:
|
21276773 - Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin d... 23165263 - The mechanobiology of brain function. 18289883 - Non-primary motor areas in the human frontal lobe are connected directly to hand muscles. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nature Volume: 490 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-12 Completed Date: 2012-11-06 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
|
Languages: eng Pagination: 226-31 Citation Subset: IM |
Affiliation:
|
Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, California 92093-0634, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Axons / metabolism Mice Postsynaptic Potential Summation / physiology* Pyramidal Cells / metabolism Retinal Neurons / cytology, physiology Visual Cortex / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
NS069010/NS/NINDS NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retinal waves coordinate patterned activity throughout the developing visual system.
Next Document: Unexpectedly large mass loss during the thermal pulse cycle of the red giant star R Sculptoris.