Document Detail

The neural basis of visuospatial perception in Alzheimer's disease and healthy elderly comparison subjects: an fMRI study.
MedLine Citation:
PMID:  19324533     Owner:  NLM     Status:  MEDLINE    
The neural basis of visuospatial deficits in Alzheimer's disease is unclear. We wished to investigate the neural basis of visuospatial perception in patients with Alzheimer's disease compared with healthy elderly comparison subjects using functional magnetic resonance imaging (fMRI). Twelve patients with AD and thirteen elderly comparison subjects were investigated. The patients were recruited from the local clinic and comparison subjects were from spouses and community. All participants underwent fMRI whilst viewing visuospatial stimuli and structural MRI, and findings were analysed using voxel-based morphometry. The comparison group activated V5, superior parietal lobe, parieto-occipital cortex and premotor cortices. The AD group demonstrated hypoactivation in the above regions and instead showed greater activation in inferior parietal lobule and activated additional areas. There was no structural atrophy above and beyond that found globally in patients in the identified regions of BOLD activation. To our knowledge, this is the first study to explore the neuroanatomy of perception of depth and motion in Alzheimer's disease. These specific functional deficits in AD provide evidence for an underlying patho-physiological basis for the clinically important symptom of visuospatial disorientation in patients with AD.
Subha N Thiyagesh; Tom F D Farrow; Randolph W Parks; Hector Accosta-Mesa; Claire Young; Iain D Wilkinson; Michael D Hunter; Peter W R Woodruff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-26
Journal Detail:
Title:  Psychiatry research     Volume:  172     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis,  physiopathology*
Brain / physiopathology*
Cognition Disorders / diagnosis,  physiopathology
Depth Perception / physiology*
Magnetic Resonance Imaging
Motion Perception / physiology*
Neuropsychological Tests
Orientation / physiology
Oxygen / blood
Space Perception / physiology
Task Performance and Analysis
Visual Perception / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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