Document Detail

The neural basis of the deficit syndrome of schizophrenia.
MedLine Citation:
PMID:  2203878     Owner:  NLM     Status:  MEDLINE    
The deficit syndrome is a domain of schizophrenic psychopathology defined by the presence of primary negative symptoms that are enduring features of a patient's function between periods of relapse. Lesions of the putative neural circuit underlying social affiliation and social behavioral cues in nonhuman primates and other mammals cause behavioral impairments in animals that model the diminished social drive, poverty of speech, and blunted affect of the deficit syndrome. Components of this circuit include the amygdala, periamygdalar cortex, and part of the prefrontal cortex. Abnormal function of this functional circuit may underlie the deficit syndrome.
B Kirkpatrick; R W Buchanan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  178     ISSN:  0022-3018     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-05     Completed Date:  1990-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-55     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Maryland Medical School, Baltimore 21228.
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MeSH Terms
Amygdala / physiopathology
Brain / pathology,  physiopathology*
Cerebral Cortex / physiopathology
Models, Neurological*
Neural Pathways / physiopathology
Schizophrenia / diagnosis,  pathology,  physiopathology*
Schizophrenic Psychology*
Social Adjustment
Social Behavior
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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