Document Detail

The network as the target.
MedLine Citation:
PMID:  20836017     Owner:  NLM     Status:  MEDLINE    
The conventional target centric model of drug discovery is pinned under the weight of prior success and the traditional problems of safety and efficacy for new molecules. An alternative to target centric drug development is to shift focus to the pathways that mediate both biology and pathophysiology. This method has the advantage of not requiring a priori knowledge of the small molecule target, but also comes with it several challenges including target determination. We suggest extending this notion more broadly across the drug discovery process using quantitative network structure-activity relationships (QNSAR), and discuss the steps necessary to test the hypothesis that systems biology approaches can be used to improve the drug discovery process.
Julie E Baggs; Michael E Hughes; John B Hogenesch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiley interdisciplinary reviews. Systems biology and medicine     Volume:  2     ISSN:  1939-005X     ISO Abbreviation:  Wiley Interdiscip Rev Syst Biol Med     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-02-23     Revised Date:  2012-03-08    
Medline Journal Info:
Nlm Unique ID:  101516550     Medline TA:  Wiley Interdiscip Rev Syst Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
Institution for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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MeSH Terms
Chemistry, Pharmaceutical / methods
Drug Discovery*
Genome, Human
Quantitative Structure-Activity Relationship
Systems Biology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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