Document Detail

The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system.
MedLine Citation:
PMID:  10068638     Owner:  NLM     Status:  MEDLINE    
Retinal axons in Drosophila make precise topographic connections with their target cells in the optic lobe. Here we investigate the role of the Netrins and their receptor Frazzled in the establishment of retinal projections. We find that the Netrins, although expressed in the target, are not required for retinal projections. Surprisingly, Frazzled, found on both retinal fibers and target cells, is required in the target for attracting retinal fibers, while playing at best a redundant role in the retinal fibers themselves; this finding demonstrates that target attraction is necessary for topographic map formation. Finally, we show that Frazzled is not required for the differentiation of cells in the target. Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule. We favor the possibility that Frazzled in the target interacts with a component on the surface of retinal fibers, possibly another Netrin receptor.
Q Gong; R Rangarajan; M Seeger; U Gaul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  126     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1451-6     Citation Subset:  IM; S    
Laboratory of Developmental Neurogenetics, The Rockefeller University, New York, NY 10021, USA.
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MeSH Terms
Axons / metabolism
Cell Differentiation
Drosophila / embryology*
Eye / embryology*
Gene Expression Regulation, Developmental / genetics
In Situ Hybridization
RNA, Messenger / genetics
Receptors, Cell Surface / genetics*
Retina / embryology*
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Cell Surface; 0/netrin receptors

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