| The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages. | |
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MedLine Citation:
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PMID: 21217078 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Macrophages infected with HIV-1 sustain viral replication for long periods, functioning as viral reservoirs. Therefore, recognition of factors that maintain macrophages alive and influence HIV-1 replication is critical to understanding the mechanisms that regulate HIV-1 replicative cycle. Because HIV-1-infected macrophages release the nerve growth factor (NGF), and NGF neutralization reduces viral production, we further analyzed how this molecule affects HIV-1 replication. Here, we show that NGF stimulates HIV-1 replication in primary macrophages by means of signaling through its high affinity receptor TrKA, and with the involvement of reticular calcium, PKC, ERK, p38 kinase, and NF-kB. NGF-induced enhancement of HIV-1 replication occurred during the late events of HIV-1 replicative cycle, with a concomitant increase in viral transcription and production. In addition, NGF reduced the synthesis of the cellular HIV-1 restriction factor APOBEC3G (A3G), as well as overrode the IFN-γ-induced up-regulation of A3G, allowing the production of a well-fitted virus. Since NGF-TrKA signaling is a crucial event for macrophage survival, it is possible that the NGF-induced HIV-1 replication plays a role for the maintenance of HIV-1 reservoirs. Our study could contribute to the understanding of immunopathogenesis of HIV-1 infection and might provide insights about approaches aimed to limit viral replication in HIV-1 reservoirs. |
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Authors:
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Thiago Moreno L Souza; Diego Q Rodrigues; Caroline P B Passaes; Victor Barreto-de-Souza; Renato S Aguiar; Jairo R Temerozo; Mariza G Morgado; Carlos Frederico L Fontes; Elizabeth G Araujo; Dumith Chequer Bou-Habib |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-7 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory on Thymus Research, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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