| The nephrotic syndrome: from the simple to the complex. | |
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MedLine Citation:
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PMID: 9613871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nephrotic syndrome represents a series of physiological results ensuing from the occurrence of significant urinary loss of protein. Although the common initiating event of proteinuria has long been established, the list of problems that result has continued to grow as our understanding of the pathophysiology of nephrosis has increased. This article discusses this pathophysiology, emphasizing the consequences of nephrotic-range proteinuria. These consequences include not only acute and subacute manifestations of disrupted homeostasis, but also ways in which nephrosis itself may amplify mechanisms by which progressive renal nephron loss occurs. New insights into the factors that initiate and maintain glomerulosclerosis and interstitial fibrosis may offer potential approaches to preventing or ameliorating chronic renal insufficiency. |
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Authors:
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A A Eddy; H W Schnaper |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 18 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-28 Completed Date: 1998-07-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 304-16 Citation Subset: IM |
Affiliation:
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Children's Hospital and Regional Medical Center, and the Department of Pediatrics, University of Washington, Seattle, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Humans Kidney / physiopathology Nephrotic Syndrome* / etiology, physiopathology, therapy |
| Grant Support | |
ID/Acronym/Agency:
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DK-49362/DK/NIDDK NIH HHS; DK-53576/DK/NIDDK NIH HHS; HL-53918/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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