Document Detail

A neonatal mouse model of intermittent hypoxia associated with features of apnea in premature infants.
MedLine Citation:
PMID:  21699999     Owner:  NLM     Status:  MEDLINE    
A neonatal mouse model of intermittent hypoxia (IH) simulating the recurring hypoxia/reoxygenation episodes of apnea of prematurity (AOP) was developed. C57BL/6 P2 pups were culled for exposure to either intermittent hypoxia or intermittent air as control. The IH paradigms consisted of alternation cycles of 20.9% O2 and either 8.0% or 5.7% O2 every 120 or 140s for 6h a day during daylight hours from day 2 to day 10 postnatally, i.e., roughly equivalent to human brain development in the perinatal period. IH exposures elicited modest to severe decrease in oxygen saturation along with bradycardia in neonatal mice, which were severity-dependent. Hypomyelination in both central and peripheral nervous systems was observed despite the absence of visible growth retardation. The neonatal mouse model of IH in this study partially fulfills the current diagnostic criteria with features of AOP, and provides opportunities to reproduce in rodents some of the pathophysiological changes associated with this disorder, such as alterations in myelination.
Jun Cai; Chi Minh Tuong; David Gozal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-15
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  178     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-06-11     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  210-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Animals, Newborn
Anoxia / diagnosis,  physiopathology*
Apnea / diagnosis,  physiopathology*
Disease Models, Animal*
Infant, Newborn
Infant, Premature* / physiology
Mice, Inbred C57BL
Grant Support
2P20RR017702-061A1/RR/NCRR NIH HHS; HL086662/HL/NHLBI NIH HHS; R01 HL086662/HL/NHLBI NIH HHS; R01 HL086662-05/HL/NHLBI NIH HHS

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