| The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty. | |
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MedLine Citation:
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PMID: 7669490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) was obtained. In addition, left ventricular pressure and contractility parameters were measured. These parameters were also measured before and after additional balloon inflations, preceded by placebo and R 56865 i.v. R 56865 was infused intravenously at three different dosages, namely: 20 mg (n = 8), 30 mg (n = 2), 40 mg (n = 2). No significant differences were observed between placebo and R 56865 (20 mg) concerning time to onset and duration of ST-segment changes and symptomatic angina pectoris, respectively. The other parameters did not show differences compared with the baseline values when R 56865 (20 and 30 mg) was infused. However, the two patients receiving a dose of 40 mg R 56865 developed a dramatic decrease in systolic and diastolic blood pressure, left ventricular (LV) systolic pressure, peak positive dP/dt and the CSBF (ranging from 30-50%), while the LV end-diastolic pressure increased by 100%. The two patients who received this dose became pale and cyanotic and did not respond to verbal commands. In summary, no anti-ischaemic effects of R 56865 were observed under these conditions, whereas at the highest dose (40 mg) R 56865 induced hypotension and a reduction in cardiac contractile force. |
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Authors:
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A J Pijl; H B Van Wezel; J J Koolen; J J Piek; K Koch; A Swaan; G K David; C A Visser; P A Van Zwieten |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 39 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-10-13 Completed Date: 1995-10-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 531-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Benzothiazoles Blood Gas Analysis Blood Pressure / drug effects Calcium Channel Blockers / administration & dosage, adverse effects, pharmacology*, therapeutic use Cardiac Output / drug effects Coronary Circulation / drug effects Coronary Disease / drug therapy, therapy* Female Humans Male Myocardial Contraction / drug effects Piperidines / administration & dosage, adverse effects, pharmacology*, therapeutic use Thiazoles / administration & dosage, adverse effects, pharmacology*, therapeutic use Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Benzothiazoles; 0/Calcium Channel Blockers; 0/Piperidines; 0/Thiazoles; 104606-13-5/R 56865 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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