Document Detail

The need to redefine preeclampsia.
MedLine Citation:
PMID:  23480743     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: The current definition of preeclampsia is based on convention and not on maternal and/or perinatal outcomes. This article reviews some of the limitations of the conventional definition of preeclampsia and recent evidence suggesting that there is a dose-response relationship between the magnitude of uteroplacental ischemia and the timing of onset of preeclampsia.
AREAS COVERED: This clinical opinion reviews the limitations of the conventional cutoff for 24-h proteinuria during pregnancy, problems with blood pressure measurement in pregnant women and recent insights into the pathophysiology of preeclampsia including the role of angiogenic imbalances.
EXPERT OPINION: New criteria to redefine preeclampsia has to rely on studies that compare the degree of proteinuria, the severity of hypertension and perhaps the magnitude of angiogenic imbalances in relation with maternal and/or perinatal outcomes. We propose a hypothetical sub-classification of preeclampsia according to whether there is evidence of absolute or relative uteroplacental ischemia in view of the lack of placental pathology support for the cutoff of 34 weeks to sub-classify preeclampsia.
Jimmy Espinoza
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Publication Detail:
Type:  Journal Article     Date:  2012-05-22
Journal Detail:
Title:  Expert opinion on medical diagnostics     Volume:  6     ISSN:  1753-0067     ISO Abbreviation:  Expert Opin Med Diagn     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-04-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101392201     Medline TA:  Expert Opin Med Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-57     Citation Subset:  -    
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