Document Detail

The need to feed: homeostatic and hedonic control of eating.
MedLine Citation:
PMID:  12383777     Owner:  NLM     Status:  MEDLINE    
Feeding provides substrate for energy metabolism, which is vital to the survival of every living animal and therefore is subject to intense regulation by brain homeostatic and hedonic systems. Over the last decade, our understanding of the circuits and molecules involved in this process has changed dramatically, in large part due to the availability of animal models with genetic lesions. In this review, we examine the role played in homeostatic regulation of feeding by systemic mediators such as leptin and ghrelin, which act on brain systems utilizing neuropeptide Y, agouti-related peptide, melanocortins, orexins, and melanin concentrating hormone, among other mediators. We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition.
Clifford B Saper; Thomas C Chou; Joel K Elmquist
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  36     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2002-11-04     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-211     Citation Subset:  IM    
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MeSH Terms
Brain / physiology
Feeding Behavior / physiology*,  psychology
Homeostasis / physiology*

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