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The need for better insulin therapy.
MedLine Citation:
PMID:  23448196     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Insulin replacement therapy corrects a core defect of diabetes pathophysiology. Since its introduction as a therapeutic modality almost 100 years ago, insulin therapy has undergone remarkable changes in purity and ability to provide more physiologic control of blood glucose levels. With glucose-lowering potential limited only by risks of hypoglycaemia, which remains the major limitation in our ability to achieve glycaemic goals, insulin replacement therapy remains a cornerstone of therapy. Major progress in reducing the risks of hypoglycemia has occurred with the development of insulin analogs. This review article briefly chronicles the evolution of insulin replacement strategies, highlighting both challenges in pharmaceutical development and patient acceptance, underscoring achievements, as well as denoting what improvements are still needed.
Authors:
G Grunberger
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  15     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Affiliation:
Grunberger Diabetes Institute, Department of Internal Medicine, Center for Molecular Medicine & Genetics, Wayne State University School of Medicine, Bloomfield Hills, MI, USA.
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