Document Detail


The need for adjustment of dosage regimen of penicillin V during pregnancy.
MedLine Citation:
PMID:  8497356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the normal regimen of dosage of oral penicillin V is relevant during pregnancy. METHODS: Twelve pregnant and six nonpregnant women volunteered for the study. Six women were in the second trimester of pregnancy (mean +/- standard deviation 19 +/- 7 weeks' gestation) and six women were in the third trimester (35 +/- 2 weeks). All of the women took 1 x 10(6) IU phenoxymethylpenicillin orally, and multiple blood and urine samples were obtained. Assays were performed by means of a disk agar diffusion method. The results were compared by Mann-Whitney U test. RESULTS: Compared with nonpregnant women, pregnant women had smaller area under the curve values (433 +/- 93 minutes.IU/mL, P < .05 in the second trimester; 550 +/- 220 minutes.IU/mL in the third trimester) and a shorter half-life (57 +/- 56 minutes in the second trimester; 34 +/- 21 minutes, P < .05 in the third trimester). Plasma and renal clearances were faster in the pregnant women. CONCLUSION: Elimination of penicillin V is enhanced during pregnancy, necessitating either a shorter dosing interval (6-8 hours) or an increased dose with the standard dosing interval.
Authors:
A M Heikkilä; R U Erkkola
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  81     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-18     Completed Date:  1993-06-18     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  919-21     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Female
Half-Life
Humans
Penicillin V / administration & dosage*,  pharmacokinetics*
Pregnancy / metabolism*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
87-08-1/Penicillin V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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