Document Detail

The need for adjustment of dosage regimen of penicillin V during pregnancy.
MedLine Citation:
PMID:  8497356     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the normal regimen of dosage of oral penicillin V is relevant during pregnancy. METHODS: Twelve pregnant and six nonpregnant women volunteered for the study. Six women were in the second trimester of pregnancy (mean +/- standard deviation 19 +/- 7 weeks' gestation) and six women were in the third trimester (35 +/- 2 weeks). All of the women took 1 x 10(6) IU phenoxymethylpenicillin orally, and multiple blood and urine samples were obtained. Assays were performed by means of a disk agar diffusion method. The results were compared by Mann-Whitney U test. RESULTS: Compared with nonpregnant women, pregnant women had smaller area under the curve values (433 +/- 93 minutes.IU/mL, P < .05 in the second trimester; 550 +/- 220 minutes.IU/mL in the third trimester) and a shorter half-life (57 +/- 56 minutes in the second trimester; 34 +/- 21 minutes, P < .05 in the third trimester). Plasma and renal clearances were faster in the pregnant women. CONCLUSION: Elimination of penicillin V is enhanced during pregnancy, necessitating either a shorter dosing interval (6-8 hours) or an increased dose with the standard dosing interval.
A M Heikkilä; R U Erkkola
Related Documents :
15791656 - Cysteinylation of maternal plasma albumin and its association with intrauterine growth ...
19902006 - Quantitative proteomics analysis of maternal plasma in down syndrome pregnancies using ...
7283366 - Free radical oxidation (peroxidation)products in plasma in normal and abnormal pregnancy.
1533486 - Changes in plasma human atrial natriuretic peptide (hanp) level in normal pregnancy and...
19276406 - Circulating and uteroplacental adipocytokine concentrations in preeclampsia.
15842276 - Prenatal diagnosis and obstetric outcomes in triplet pregnancies in relation to chorion...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  81     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-18     Completed Date:  1993-06-18     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  919-21     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Penicillin V / administration & dosage*,  pharmacokinetics*
Pregnancy / metabolism*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Reg. No./Substance:
87-08-1/Penicillin V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Abnormal cervical cytology in pregnancy: a 17-year experience.
Next Document:  Preoperative skin preparation and intraoperative pelvic irrigation: impact on post-cesarean endometr...