Document Detail

A necrotic skin lesion in a dialysis patient after the initiation of warfarin therapy: a difficult diagnosis.
MedLine Citation:
PMID:  19267184     Owner:  NLM     Status:  MEDLINE    
Necrotic skin lesions are unfortunately common in patients with end stage renal disease undergoing dialysis therapy. We present a case of a necrotic skin lesion in a peritoneal dialysis patient shortly after the initiation of warfarin therapy for atrial fibrillation. We discuss and contrast distinguishing features of two diagnostic possibilities: warfarin skin necrosis (WSN) and calcific uremic arteriopathy (CUA) in terms of clinical presentation, risk factors and pathology. Lastly, we outline the importance of establishing a diagnosis as treatment regimens differ substantially.
Marie Antoinette Rockx; Manish M Sood
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  29     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
Department of Medicine, Section of Nephrology, St. Boniface Hospital, University of Manitoba, Rm #BG007, 409 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada.
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MeSH Terms
Anticoagulants / adverse effects*
Calciphylaxis / diagnosis
Diabetic Nephropathies / complications*
Diagnosis, Differential
Kidney Failure, Chronic / complications*
Middle Aged
Skin Diseases / chemically induced*,  pathology
Warfarin / adverse effects*
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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