| The necessity for T-cryptantigen activation screening in babies with necrotising enterocolitis. | |
| | |
MedLine Citation:
|
PMID: 8711554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the prevalence of T-cryptantigen activation (TCA) and its predictive value for severity of necrotising enterocolitis (NEC) in babies. STUDY DESIGN: Prospective descriptive. STUDY POPULATION: Thirty-four babies with NEC were prospectively screened for TCA at Tygerberg Hospital over a 6-month period. TCA screening was done by testing for red blood cell agglutination by the common peanut lectin, Arachis hypogea. Once TCA was confirmed, only washed red cells were administered to the babies and plasma-containing blood products were avoided. NEC was divided into suspected NEC (stage 1), classic NEC (stage 2) and fulminant NEC (stage 3). MAIN OUTCOME MEASURES: Prevalence of TCA in babies with various stages of NEC; the association between TCA and bowel necrosis, need for surgery and mortality. RESULTS: TCA was positive in 8 (24%) of the babies in this study. Six babies (18%) had stage 1 NEC, 10 (29%) had stage 2 NEC and 18 (53%) had fulminating or stage 3 NEC. All 18 babies with stage 3 NEC required surgery and TCA was present in 8 (47%) of them. Twelve babies (35%) died, 3 with TCA and 9 with no TCA. Babies with TCA had portal venous gas on abdominal radiographs (P = 0.037) and stage 3 NEC (P = 0.003) more often than babies with no TCA. CONCLUSIONS: A strong association was noted between TCA and the fulminant form of NEC with bowel necrosis. TCA is a baby with NEC should alert the surgeon to the possibility of severe disease and the need to avoid plasma-containing blood products. Blood banks are urged to introduce routine screening for TCA in all babies with NEC. |
| | |
Authors:
|
G F Kirsten; J Smith; C Pieper; A Bird; G Wessels; S Riphagen; S Moore |
Related Documents
:
|
724324 - Manometric diagnosis of lower esophageal sphincter incompetence in infants: use of a sm... 1238014 - Cardiac catheterization in small infants: the percutaneous approach. 8370014 - Surgical and postoperative management of two neonates with necrotizing fasciitis. 3564964 - Loperamide associated necrotising enterocolitis. 14991914 - Secular decreasing trend of the frequency of hypospadias among newborn male infants in ... 6825374 - The winnecott "set situation". a useful tool for the pediatrician. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 86 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1996 May |
Date Detail:
|
Created Date: 1996-09-12 Completed Date: 1996-09-12 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
|
Languages: eng Pagination: 546-8 Citation Subset: IM |
Affiliation:
|
Department of Paediatrics Tygerberg Hospital, W. Cape. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antigens, Tumor-Associated, Carbohydrate
/
blood* Enterocolitis, Pseudomembranous / diagnosis*, immunology, surgery Erythrocytes / immunology Humans Infant Infant, Newborn Isoantigens / blood* Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Tumor-Associated, Carbohydrate; 0/Isoantigens; 3554-90-3/Thomsen-Friedenreich antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intravenous immunoglobulin prophylaxis in neonates on artificial ventilation.
Next Document: A phase II trial of fludarabine in patients with previously treated chronic lymphocytic leukaemia.