Document Detail

The near-term (late preterm) human brain and risk for periventricular leukomalacia: a review.
MedLine Citation:
PMID:  16731282     Owner:  NLM     Status:  MEDLINE    
Historically the major focus in neonatal neurology has been on brain injury in premature infants born less than 30 gestational weeks. This focus reflects the urgent need to improve the widely recognized poor neurological outcomes that occur in these infants. The most common underlying substrate of cerebral palsy in these premature infants is periventricular leukomalacia (PVL). Nevertheless, PVL also occurs in near-term (late preterm), as well as term, infants, as documented by neuroimaging and autopsy studies. In both very preterm and late preterm infants, gray matter injury is associated with PVL. In this review, we discuss the cellular pathology of PVL and the developmental parameters in oligodendrocytes and neurons that put the late preterm brain at risk in the broader context of brain development and injury close to term. Further research is needed about the clinical and pathologic aspects of brain injury in general and PVL in particular in late preterm infants to optimize management and prevent adverse neurological outcomes in these infants that, however subtle, may be currently underestimated.
Hannah C Kinney
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  30     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Department of Pathology, Children's Hospital Boston and Harvard Medical School, MA 02115, USA.
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MeSH Terms
Antioxidants / metabolism
Axons / metabolism,  pathology
Brain / growth & development*,  metabolism,  pathology*
Enzymes / metabolism
Gestational Age
Infant, Newborn
Infant, Premature
Leukomalacia, Periventricular / epidemiology*,  etiology*,  pathology
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Enzymes

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