Document Detail

The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS): study design and methods.
MedLine Citation:
PMID:  23149275     Owner:  NLM     Status:  MEDLINE    
The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS) was designed to examine the relationship between near-roadway exposures to air pollutants and respiratory outcomes in a cohort of asthmatic children who live close to major roadways in Detroit, Michigan USA. From September 2010 to December 2012 a total of 139 children with asthma, ages 6-14, were enrolled in the study on the basis of the proximity of their home to major roadways that carried different amounts of diesel traffic. The goal of the study was to investigate the effects of traffic-associated exposures on adverse respiratory outcomes, biomolecular markers of inflammatory and oxidative stress, and how these exposures affect the frequency and severity of respiratory viral infections in a cohort of children with asthma. An integrated measurement and modeling approach was used to quantitatively estimate the contribution of traffic sources to near-roadway air pollution and evaluate predictive models for assessing the impact of near-roadway pollution on children's exposures. Two intensive field campaigns were conducted in Fall 2010 and Spring 2011 to measure a suite of air pollutants including PM2.5 mass and composition, oxides of nitrogen (NO and NO2), carbon monoxide, and black carbon indoors and outdoors of 25 participants' homes, at two area schools, and along a spatial transect adjacent to I-96, a major highway in Detroit. These data were used to evaluate and refine models to estimate air quality and exposures for each child on a daily basis for the health analyses. The study design and methods are described, and selected measurement results from the Fall 2010 field intensive are presented to illustrate the design and successful implementation of the study. These data provide evidence of roadway impacts and exposure variability between study participants that will be further explored for associations with the health measures.
Alan Vette; Janet Burke; Gary Norris; Matthew Landis; Stuart Batterman; Michael Breen; Vlad Isakov; Toby Lewis; M Ian Gilmour; Ali Kamal; Davyda Hammond; Ram Vedantham; Sarah Bereznicki; Nancy Tian; Carry Croghan;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-10
Journal Detail:
Title:  The Science of the total environment     Volume:  448     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  38-47     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Air Pollutants / analysis*,  chemistry,  toxicity
Asthma / complications,  epidemiology*
Biological Markers / metabolism
Cells, Cultured
Cohort Studies
Environmental Monitoring / methods*
Inflammation / chemically induced,  metabolism
Michigan / epidemiology
Models, Theoretical
Motor Vehicles
Respiratory Tract Infections / complications,  epidemiology,  virology
Soot / analysis,  toxicity
Vehicle Emissions / analysis*,  toxicity
Grant Support
5-R01-ESO14677-02//PHS HHS; P30 ES017885/ES/NIEHS NIH HHS; R01 ES014677/ES/NIEHS NIH HHS; R01 ES016769/ES/NIEHS NIH HHS; R01 ES016769-01/ES/NIEHS NIH HHS
Reg. No./Substance:
0/Air Pollutants; 0/Biological Markers; 0/Soot; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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