Document Detail


A near-infrared spectroscopic investigation of relative density and crushing strength in four-component compacts.
MedLine Citation:
PMID:  18623193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Near-infrared spectroscopy (NIRS) is commonly employed for the analysis of chemical and physical attributes of intact pharmaceutical compacts. Specifically, NIRS has proven useful in the nondestructive measurement of tablet hardness or crushing strength. Near-infrared (NIR) reflectance and transmittance spectra were acquired for 174 13-mm compacts, which were produced according to a four-constituent mixture design (29 points) composed of anhydrous theophylline, lactose monohydrate, microcrystalline cellulose, and soluble starch. Six compacts were produced for each design point by compacting at multiple pressures. Physical testing and regression analyses were used to model the effect of variation in relative density (and crushing strength) on NIR spectra. Chemometric analyses demonstrated that the overall spectral variance was strongly influenced by anhydrous theophylline as a result of the experimental design and the component's spectroscopic signature. The calibration for crushing strength was more linear than the relative density model, although accuracy was poorer in comparison to the density model due to imprecision of the reference measurements. Based on the consideration of reflectance and transmittance measurements, a revised rationalization for NIR sensitivity to compact hardness is presented.
Authors:
Steven M Short; Robert P Cogdill; Peter L D Wildfong; James K Drennen; Carl A Anderson
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  98     ISSN:  1520-6017     ISO Abbreviation:  J Pharm Sci     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-109     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association
Affiliation:
Duquesne University Graduate School of Pharmaceutical Sciences, 410A Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA.
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MeSH Terms
Descriptor/Qualifier:
Calibration
Cellulose / chemistry
Drug Compounding
Hardness Tests*
Lactose / chemistry
Least-Squares Analysis
Spectroscopy, Near-Infrared / methods*
Starch / chemistry
Tablets / chemistry*
Theophylline / chemistry
Chemical
Reg. No./Substance:
0/Tablets; 0/microcrystalline cellulose; 58-55-9/Theophylline; 63-42-3/Lactose; 9004-34-6/Cellulose; 9005-25-8/Starch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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