Document Detail

The nature of host tissue destruction in tumor invasion. An experimental investigation on carcinoma and sarcoma xenotransplants.
MedLine Citation:
PMID:  2884773     Owner:  NLM     Status:  MEDLINE    
The nature of host tissue destruction in tumor invasion was investigated in experimentally induced carcinomas and sarcomas, xenografted into skeletal muscle. By means of light and electron microscopy it was shown that in both carcinomas and sarcomas the confrontation of host tissue with the invading tumor cells does not result in immediate destruction of host tissue but in a transitory state of coexistence which gradually proceeds to progressive host tissue atrophy. This process of progressive atrophy, which finally results in the total disappearance of the invaded host tissue, is considered to be caused mainly by the increasing pressure and competitive withdrawal of oxygen and nutrients by the invading and proliferating tumor cells. Morphological changes suggesting an active enzymatic breakdown of host tissue cells by tumor cells were not observed during any stage of tumor invasion.
H Gabbert; C D Gerharz; U Ramp; J Bohl
Related Documents :
21534933 - Accuracy of intra-operative gross visual assessment of myometrial invasion in endometri...
6546593 - Anaesthesia and development of some experimental tumours.
19644423 - Prognostic value of immunohistochemistry in the ewing's sarcoma family of tumors.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virchows Archiv. B, Cell pathology including molecular pathology     Volume:  52     ISSN:  0340-6075     ISO Abbreviation:  Virchows Arch., B, Cell Pathol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-14     Completed Date:  1987-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9316922     Medline TA:  Virchows Arch B Cell Pathol Incl Mol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  513-27     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / chemically induced,  pathology*
Mice, Nude
Microscopy, Electron
Muscles / pathology*
Muscular Atrophy / etiology
Neoplasm Invasiveness / pathology*
Neoplasm Transplantation
Rats, Inbred Lew
Sarcoma, Experimental / chemically induced,  pathology*
Transplantation, Heterologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in the acinar distribution of some enzymes involved in carbohydrate metabolism in rat liver ...
Next Document:  Ultrastructural localization of mercury in adrenals from rats exposed to methyl mercury.