Document Detail


The nature of host tissue destruction in tumor invasion. An experimental investigation on carcinoma and sarcoma xenotransplants.
MedLine Citation:
PMID:  2884773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nature of host tissue destruction in tumor invasion was investigated in experimentally induced carcinomas and sarcomas, xenografted into skeletal muscle. By means of light and electron microscopy it was shown that in both carcinomas and sarcomas the confrontation of host tissue with the invading tumor cells does not result in immediate destruction of host tissue but in a transitory state of coexistence which gradually proceeds to progressive host tissue atrophy. This process of progressive atrophy, which finally results in the total disappearance of the invaded host tissue, is considered to be caused mainly by the increasing pressure and competitive withdrawal of oxygen and nutrients by the invading and proliferating tumor cells. Morphological changes suggesting an active enzymatic breakdown of host tissue cells by tumor cells were not observed during any stage of tumor invasion.
Authors:
H Gabbert; C D Gerharz; U Ramp; J Bohl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virchows Archiv. B, Cell pathology including molecular pathology     Volume:  52     ISSN:  0340-6075     ISO Abbreviation:  Virchows Arch., B, Cell Pathol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-14     Completed Date:  1987-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9316922     Medline TA:  Virchows Arch B Cell Pathol Incl Mol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  513-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemically induced,  pathology*
Animals
Mice
Mice, Nude
Microscopy, Electron
Muscles / pathology*
Muscular Atrophy / etiology
Neoplasm Invasiveness / pathology*
Neoplasm Transplantation
Rats
Rats, Inbred Lew
Sarcoma, Experimental / chemically induced,  pathology*
Transplantation, Heterologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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