Document Detail

The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption.
MedLine Citation:
PMID:  17761015     Owner:  NLM     Status:  MEDLINE    
The nutritional cues which induce different phenotypes from a single genotype in developing offspring are poorly understood. How well prenatal nutrient availability before birth predicts that after birth may also determine the offspring's response to later metabolic challenge. We investigated the effect of feeding pregnant rats diets containing protein at 180 g/kg (Control) or 90 g/kg (protein-restricted, PR) and either 1 or 5 mg folic acid/kg on growth and metabolic response to fasting in their offspring, and also the effect of diets with different fat contents (40 g/kg (Fat(4)) or 100 g/kg (Fat(10))) after weaning. Offspring of dams fed the PR diet with 5 mg/kg folic acid were significantly lighter than other offspring. The PR offspring fed the Fat(4) diet had lower plasma TAG than the Control offspring, but this relationship was reversed when offspring were fed Fat(10). Increasing the folic acid content of the Control or PR maternal diets induced opposing effects on plasma TAG, NEFA, beta-hydroxybutyrate and glucose concentrations in offspring fed Fat(4). The effect was accentuated in offspring fed the Fat(10) diet such that these metabolites were increased in the Control offspring, but reduced in the PR offspring. These data show for the first time that maternal dietary folic acid intake alters offspring phenotype depending upon dietary protein intake, and that this effect is modified by fat intake after weaning. Prevention by increased folic acid intake of an altered metabolic phenotype by maternal protein-restriction may be at the expense of somatic growth.
Graham C Burdge; Karen A Lillycrop; Alan A Jackson; Peter D Gluckman; Mark A Hanson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-29
Journal Detail:
Title:  The British journal of nutrition     Volume:  99     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-04-04     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  540-9     Citation Subset:  IM    
Institute of Human Nutrition, University of Southampton, Southampton, SO16 6YD, UK.
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MeSH Terms
Blood Glucose / metabolism
Body Weight
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage*
Eating / physiology
Fasting / metabolism*
Folic Acid / administration & dosage*
Growth / physiology*
Heart / anatomy & histology
Lactation / physiology
Lipids / blood
Liver / anatomy & histology
Organ Size
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena / physiology*
Grant Support
FS/05/064/19525//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Dietary Proteins; 0/Lipids; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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