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The nature of cytotoxic drug-induced cell death in murine intestinal crypts.
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MedLine Citation:
PMID:  1562464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nature of cell death in murine small intestinal crypts caused by potentially lethal doses of four classes of cancer chemotherapeutic agents was studied. The drugs used were cytosine arabinoside, vincristine, adriamycin and nitrogen mustard. The compounds readily induced massive cell death in the proliferating compartment of the crypt. In each case, cell death was apparent within an hour, and the incidence of dead cells peaked during the following 4-8 h. By 24 h, little damage was discernible in the crypt systems. Remarkably, dead cells or dead cell fragments were phagocytosed rapidly (within about 1 h) by neighbouring healthy enterocytes. When examined by light microscopy, transmission electron microscopy and scanning electron microscopy, the dead cells showed the characteristic features of having succumbed to an apoptotic mode of cell death without any trace of cell and organelle oedema characteristic of necrosis. The study suggests that cell death by apoptosis operates even when the cells are exposed to severe pathological perturbation and that the phenomenon is not solely a process which operates in response to either physiological stimuli or to mild physical or chemical trauma.
Authors:
T V Anilkumar; C E Sarraf; T Hunt; M R Alison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of cancer     Volume:  65     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-19     Completed Date:  1992-05-19     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  552-8     Citation Subset:  IM    
Affiliation:
Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death / drug effects
Cytarabine / toxicity*
Doxorubicin / toxicity*
Drug Administration Schedule
Intestinal Mucosa / drug effects*,  ultrastructure
Male
Mice
Mice, Inbred BALB C
Microscopy, Electron
Mitosis / drug effects
Nitrogen Mustard Compounds / toxicity*
Vincristine / toxicity*
Chemical
Reg. No./Substance:
0/Nitrogen Mustard Compounds; 147-94-4/Cytarabine; 23214-92-8/Doxorubicin; 57-22-7/Vincristine
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 4 Year: 1992
Volume: 65 Issue: 4
First Page: 552 Last Page: 558
ID: 1977577
PubMed Id: 1562464

The nature of cytotoxic drug-induced cell death in murine intestinal crypts.
T. V. Anilkumar
C. E. Sarraf
T. Hunt
M. R. Alison
Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.



Article Categories:
  • Research Article


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