Document Detail

The nature of aleutian disease in mink. I. Two forms of hypergammaglobulinemia as related to method of disease transmission and type of lesion.
MedLine Citation:
PMID:  977996     Owner:  NLM     Status:  MEDLINE    
Aleutian mink disease is generally considered to precipitate spontaneously in ranch mink, with a lethal outcome. A two-year field study of a herd of susceptible mutant mink (sapphires and violets), however, has shown that all individual mink were affected from birth; the well state consisted of periodic low-level hypergammaglobulinemia accompanied by minute vascular occlusions. The spontaneous lethal change in an individual appeared to arise during one of these hypergammaglobulinemic episodes and thus represented a failure of the immune system to control an inherent virus-induced mononucleosis. The fact that the entire herd was affected by the periodic form from birth is considered strong evidence for vertical transmission at a rate of 100%. The incidence of spontaneous precipitation was found to be dependent on the level of hypergammaglobulinemia in the mother during pregnancy.
P L Bazeley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  134     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Aleutian Mink Disease / blood*,  pathology,  transmission
Animals, Newborn / blood
Kidney / pathology
Pulmonary Fibrosis / pathology,  veterinary

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