Document Detail

The natural history of multiple sclerosis: implications for trial design.
MedLine Citation:
PMID:  10499179     Owner:  NLM     Status:  MEDLINE    
The understanding of the natural history of multiple sclerosis has many implications for the design and interpretation of randomized controlled trials. Selection criteria, patient stratification, outcome measurements, and definitions of treatment failure can influence randomized controlled trial results and limit comparisons among trials. The focus of future studies should shift from short-term determinations of efficacy to definitive evaluations of long-term effectiveness. This will require novel investigative strategies such as the use of historic controls derived from natural history studies.
D M Wingerchuk; B G Weinshenker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  12     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  IM    
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Disease Progression
Multiple Sclerosis / physiopathology*,  therapy
Randomized Controlled Trials as Topic / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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