Document Detail

The natural history of mesial temporal lobe epilepsy.
MedLine Citation:
PMID:  18317276     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Mesial temporal lobe epilepsy is the most common indication for epilepsy surgery, yet little is known about its 'natural' history from initial onset. The review considers the available evidence and gaps in our current knowledge of the subject.
RECENT FINDINGS: Although usually surgically treated in adulthood, the majority of people with refractory mesial temporal lobe epilepsy have their initial onset in childhood and adolescence. The course of the disorder is complex and may appear relatively benign at first with intractable seizures emerging only later. Early diagnosis of mesial temporal lobe epilepsy is made difficult due to the near absence of its MRI correlate, i.e. hippocampal atrophy, a lesion that seems to develop over time and is rarely present at initial onset. Early diagnosis is further complicated by the fact that there are likely many different entities that are localized to the temporal regions and are not clearly differentiated from each other initially.
SUMMARY: Advances in understanding mesial temporal lobe epilepsy will require concerted efforts to characterize epilepsy with precision from onset and document its course over prolonged periods of time. Better recognition of specific subtypes currently lumped together as temporal lobe epilepsy is also needed.
Anne T Berg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  21     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-06-13     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Department of Biology, Northern Illinois University, DeKalb, Illinois 60115, USA.
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MeSH Terms
Age Factors
Atrophy / etiology,  pathology,  physiopathology
Disease Progression
Early Diagnosis
Epilepsy / etiology,  physiopathology,  surgery
Epilepsy, Temporal Lobe / diagnosis*,  physiopathology*,  surgery
Hippocampus / pathology*,  physiopathology*,  surgery
Neurosurgical Procedures / standards
Prospective Studies
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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