Document Detail

The natural history of hepatocellular carcinoma.
MedLine Citation:
PMID:  1315595     Owner:  NLM     Status:  MEDLINE    
Prospective studies of patients with cirrhosis who are at risk for developing hepatocellular carcinoma (HCC), have greatly improved our understanding of the natural history of this tumour. Despite many studies, the controversy of whether HCC originates from one or more than one clone of transformed liver cells is still unsettled. The natural history of HCC in many instances is an extension of that of the underlying cirrhosis, although the course of the tumour disease may vary from patient to patient and in different geographical areas. In Oriental and southern European patients with HCC, a longer time may elapse between diagnosis and death, than in African blacks. The information about tumour development in non-cirrhotic liver is scanty, due to the little known risk factors for this type of tumour which has impeded performing prospective cohort studies of high risk patients.
M Colombo; A Sangiovanni
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The Italian journal of gastroenterology     Volume:  24     ISSN:  0392-0623     ISO Abbreviation:  Ital J Gastroenterol     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-06-08     Completed Date:  1992-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000544     Medline TA:  Ital J Gastroenterol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Istituto di Medicina Interna, Università di Milano, Italy.
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MeSH Terms
African Continental Ancestry Group*
Asian Continental Ancestry Group*
Carcinoma, Hepatocellular / ethnology,  etiology*,  mortality,  pathology
Cell Transformation, Neoplastic / pathology*
European Continental Ancestry Group*
Liver / pathology*
Liver Cirrhosis / complications*,  ethnology,  pathology
Liver Neoplasms / ethnology,  etiology*,  mortality,  pathology
Prospective Studies
South Africa

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