Document Detail


The natural history of fetal cytomegalovirus infection as assessed by serial ultrasound and fetal blood sampling: a case report.
MedLine Citation:
PMID:  7659689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient in whom intrauterine fetal cytomegalovirus (CMV) infection was diagnosed at approximately 25 weeks' gestation is presented. The fetus was evaluated by serial fetal blood samplings and ultrasound examinations. The fetus manifested evidence of severe thrombocytopenia and hepatic inflammation, with recovery over a period of approximately 8 weeks. The initial sonographic findings of marked fetal ascites and cardiomegaly gradually resolved; ventriculomegaly developed during the third trimester. At delivery, the baby was morphologically normal with the exception of mild ventriculomegaly. Cord blood was negative for CMV IgM but urine was culture-positive for CMV. At age 3, the child has a severe but stable unilateral hearing deficit and is otherwise developmentally normal. This case demonstrates the utility of serial ultrasound and fetal blood sampling in the prenatal diagnosis and management of fetal CMV infection.
Authors:
M L Watt-Morse; S A Laifer; L M Hill
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  15     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  567-70     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood
Cytomegalovirus / immunology,  isolation & purification
Cytomegalovirus Infections / ultrasonography*,  virology
Female
Fetal Blood / virology*
Fetal Diseases / ultrasonography,  virology*
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Pregnancy
Ultrasonography, Prenatal*
Urine / microbiology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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