Document Detail

The natural history of epistaxis in hereditary hemorrhagic telangiectasia.
MedLine Citation:
PMID:  1886446     Owner:  NLM     Status:  MEDLINE    
The purpose of this retrospective study is to document the natural history of epistaxis in patients with hereditary hemorrhagic telangiectasia. A telephone questionnaire was administered to 73 patients who had been previously screened for pulmonary arteriovenous malformations (PAVMs). The incidence of epistaxis in this population was 93%, with a mean onset age of epistaxis of 12 years, a mean frequency of bleeding of 18 episodes per month, and a mean duration of bleeding of 7.5 minutes. More than 90% of patients experienced the onset of epistaxis before the age of 21 and symptoms were progressive with age. There were no differences in the age of onset, frequency of epistaxis, or duration of epistaxis between patients with PAVMs versus those without PAVMs. Although the natural history of epistaxis does not predict the presence or absence of pulmonary arteriovenous malformations, epistaxis is an early marker of the disease, hereditary hemorrhagic telangiectasia, and might guide screening for pulmonary and cerebral arteriovenous malformations in children of affected parents.
O S AAssar; C M Friedman; R I White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  101     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  977-80     Citation Subset:  IM    
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Conn.
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MeSH Terms
Age Factors
Child, Preschool
Epistaxis / etiology*,  therapy
Middle Aged
Telangiectasia, Hereditary Hemorrhagic / complications*
Time Factors

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