| The natural history of colorectal adenomas and early cancer. | |
| | |
MedLine Citation:
|
PMID: 22945585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Adenomas represent the morphological precursors of the vast majority of colorectal cancers: although every adenoma has the capacity of malignant evolution, most adenomas stabilize their progression or even regress. Pathological factors are predictive of the natural history of adenomas in terms of potential and time interval for becoming malignant. Regression of adenomas is histologically well established, but it is thought to be a dynamic process, with cycling phases of regression and growth. Colorectal carcinoma invading the submucosa but not the muscular layer represents the earliest form of clinically relevant colorectal cancer. Grade of differentiation of carcinoma, lymphovascular invasion, and state of the resection margin predict the risk of metastasis. Microstaging of invasive cancer together with tumuor budding allow the metastatic risk to be further stratified into minimal, low, and high. Two distinct profiles are identifiable in the natural history of cancerous adenomas: blocking the growth of early cancer and allowing its progression towards advanced cancer. Thus, biomarkers to distinguish between progressive and non-progressive pT1 neoplasia are needed. |
| | |
Authors:
|
M Risio |
Related Documents
:
|
14720015 - Eosinophilic bronchitis: clinical features, management and pathogenesis. 19153025 - Pulmonary metastasectomy in colorectal cancer: time for a trial. 23632235 - Effect of conjugated linoleic acid supplementation on inflammatory factors and matrix m... 12945005 - Another face of bronchiolitis obliterans organizing pneumonia. 14583995 - Gauze and tape and transparent polyurethane dressings for central venous catheters. 23447335 - Identification of kazinol q, a natural product from formosan plants, as an inhibitor of... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-5 |
Journal Detail:
|
Title: Der Pathologe Volume: - ISSN: 1432-1963 ISO Abbreviation: Pathologe Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006541 Medline TA: Pathologe Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pathology, Institute for Cancer Research and Treatment, Strada Provinciale 142, 10060, Candiolo-Torino, Italy, mauro.risio@ircc.it. |
Vernacular Title:
|
Die natürliche Entwicklung des kolorektalen Adenoms und frühen Karzinoms. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hormesis: improving predictions in the low-dose zone.
Next Document: Revealing the Absolute Configuration of the CO and CN(-) Ligands at the Active Site of a [NiFe] Hydr...