Document Detail

The natural history of chronic urticaria in childhood: A prospective study.
MedLine Citation:
PMID:  25023899     Owner:  NLM     Status:  Publisher    
BACKGROUND: There are few prospective studies on the natural course of chronic urticaria (CU) in children.
OBJECTIVE: We sought to examine the natural history of CU in children and to identify predictors for remission.
METHODS: Children 4 to 15 years of age with CU were investigated with a complete blood cell count, erythrocyte sedimentation rate, antinuclear antibody titer, complement CH50 level, thyroid studies, autologous serum skin test, skin-prick tests, food challenges, and stool examination for parasites. They were considered to be in remission if symptoms did not recur for at least 12 months without medication.
RESULTS: In all, 92 children (53.3% female) with CU were recruited and followed up for a median duration of 4.3 years (range 2.5-5.8 years). Chronic autoimmune urticaria (CAU) was identified in 40% of the patients. Food allergy was found in 8.7% and parasitic infestations in 5.4%. Remission rates at 1, 3, and 5 years after the onset of CU symptoms were 18.5%, 54%, and 67.7%, respectively. The remission rate did not differ in CAU compared with non-CAU. No predictor of CU remission was identified.
LIMITATIONS: The basophil histamine release assay was not performed.
CONCLUSION: Children with CU have a favorable outcome. CAU did not have an intractable course.
Somboon Chansakulporn; Sureerat Pongpreuksa; Preeda Sangacharoenkit; Punchama Pacharn; Nualanong Visitsunthorn; Pakit Vichyanond; Orathai Jirapongsananuruk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-11
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  -     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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