Document Detail

The natural history of asymptomatic osteonecrosis of the femoral head.
MedLine Citation:
PMID:  23340674     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To observe the natural history of asymptomatic osteonecrosis of the femoral head, and to analyse the associations between the subsequent development of symptoms, epidemiological risk factors and the character of the lesions.
METHODS: Sixty-eight patients were diagnosed with asymptomatic osteonecrosis of the femoral head. The patients were classified based on the development of symptoms. Relations were sought between symptom development and epidemiological risk factors, and the size and location of the necrotic lesions.
RESULTS: Thirty-eight patients developed symptoms (55.9%) at a mean 2.27 years after diagnosis. Symptoms developed in 18 of 28 patients with alcohol-related necrosis (64.3%), in eight of 14 patients with steroid-related necrosis (57.1%), and in 12 of 26 patients with idiopathic necrosis (46.2%). None of the following: gender, age, body mass index (BMI), smoking status, or cholesterol level, was found to be significantly associated with the development of symtoms in asymptomatic osteonecrosis of femoral head (ONFH). Duration and amount of exposure to steroid were not significantly associated with symptom development. In the groups of heavy alcohol drinkers, large necrotic lesions and laterally located lesions showed a higher prevalence of symptom development.
CONCLUSION: Symptoms developed in 55.9% of asymptomatic osteonecrosis of the femoral head. Prevalence of symptom development was significantly higher in heavy alcohol drinkers and large-sized lateral lesions.
Joon Soon Kang; Kyoung Ho Moon; Dae Gyu Kwon; Byung Ki Shin; Min Su Woo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-23
Journal Detail:
Title:  International orthopaedics     Volume:  37     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-06-28     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Cohort Studies
Femur Head Necrosis / diagnosis*,  epidemiology*
Middle Aged
Risk Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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