Document Detail

The natural history of IgE sensitisation and atopic disease in early childhood.
MedLine Citation:
PMID:  2929347     Owner:  NLM     Status:  MEDLINE    
We have prospectively followed 57 children of atopic parents up to 5 years of age, documenting clinical atopic disease and allergen skin test reactions. The cumulative prevalences of the clinical features of atopic disease over the 5 years were: atopic dermatitis (58%), wheeze (49%), recurrent wheeze (33%), rhinitis (68%) and immediate food reactions (18%). Atopic dermatitis and immediate food reactions predominated in infancy (birth to 20 months) while wheezing was more prominent in later childhood (20 months to 5 years). Rhinitis was common in both infancy and childhood. IgE sensitisation to ingested allergens was prominent in early infancy and was usually transient. Inhaled allergen sensitisation occurred later in infancy and was generally permanent with wheal sizes tending to increase with age. There was a significant association between IgE sensitisation to ingested but not inhaled allergens and all atopic manifestations in infancy, with the exception of rhinitis. In contrast IgE sensitisation to inhaled allergens was associated with rhinitis and wheeze in later childhood. We found two clinical groups. One group, with only ingested allergen sensitisation had a high incidence of atopic dermatitis but low incidence of respiratory symptoms at 5 years of age. The other group, who developed evidence of IgE sensitisation to inhaled allergens, had a high incidence of rhinitis and wheeze but low incidence of atopic dermatitis at 5 years of age.
P P van Asperen; A S Kemp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  78     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-28     Completed Date:  1989-04-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Department of Respiratory Medicine, Children's Hospital, Camperdown, Sydney, Australia.
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MeSH Terms
Age Factors
Allergens / diagnostic use
Child, Preschool
Dermatitis, Atopic / immunology
Food Hypersensitivity / immunology
Hypersensitivity, Immediate / immunology*
Immunoglobulin E / immunology*
Infant, Newborn
Prospective Studies
Respiratory Sounds / etiology
Rhinitis / immunology
Skin Tests
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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