Document Detail

A nationwide survey of lymphangioleiomyomatosis in Korea: recent increase in newly diagnosed patients.
MedLine Citation:
PMID:  20676330     Owner:  NLM     Status:  MEDLINE    
In 2007, the Korean Interstitial Lung Disease Society had collected clinical data of patients who have diagnosed as Lymphangioleiomyomatosis (LAM) since 1990 through nationwide survey, which showed that LAM patients had increased sharply after 2004. The present study was performed to show the clinical features of Korean patients with LAM, and to establish the reason for the recent increase in the diagnosis. All 63 patients were women and the mean age at diagnosis was 36 yr. The most common presenting symptom was dyspnea and 8 patients had tuberous sclerosis complex. The survival rate at 5 yr after diagnosis was 84%. Compared with patients diagnosed after 2004 (n=34), the patients diagnosed before 2004 (n=29) complained with dyspnea more (P=0.016) and had lower FEV(1)% predicted (P=0.003), and DLco% predicted (P=0.042). The higher proportion of patients diagnosed after 2004 showed the normal chest radiography, and they were detected by routine chest CT screening (P=0.016). This study showed that clinical features of Korean patients with LAM were not different from those reported elsewhere. It is concluded that the reason for the increase of newly diagnosed patients is the result of increase in detection of the early stage LAM by the widespread use of chest CT screening.
Hye Yun Park; Hae-Seong Nam; Man Pyo Chung; Sung Hwan Jeong; Yu Jin Kim; Seung-Ick Cha; Young Whan Kim; Jong Sun Park; Soo-Taek Uh; Choon-Sik Park; Moo Suk Park; Ji Ae Moon; Kyung Soo Jung; Yang Jin Jegal; Dong Soon Kim; Jin Woo Song; Ho-Kee Yum; Young Bum Park
Publication Detail:
Type:  Journal Article     Date:  2010-07-21
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1182-6     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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MeSH Terms
Early Diagnosis
Lung Neoplasms / diagnosis*,  mortality,  radiography
Lymphangioleiomyomatosis / diagnosis*,  mortality,  radiography
Middle Aged
Republic of Korea
Respiratory Function Tests
Survival Rate
Tomography, X-Ray Computed

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