Document Detail

The narcotic-dependent mother: fetal and neonatal consequences.
MedLine Citation:
PMID:  617308     Owner:  NLM     Status:  MEDLINE    
During the years 1971--1974, 230 infants born to drug-dependent women and 33 infants born to ex-addicts were studied. Heroin abuse declined while methadone usage increased during those years. Compared to heroin abuse, methadone maintenance treatment during pregnancy was associated with more consistent prenatal care, more normal fetal growth and reduced fetal mortality. Meconium staining of amniotic fluid was increased in the heroin and heroin-methadone groups; this was not associated, however, with an increase in meconium aspiration or a reduction in Apgar scores. Of special note was the equally severe intrauterine growth retardation of infants of former heroin addicts who were free of narcotic use during pregnancy. Neonatal withdrawal from methadone appeared to be more severe than from heroin, as judged by amount of medication required to control symptoms and duration of treatment. In all groups, central nervous system signs were the most common manifestations of withdrawal. Severity of withdrawal did not correlate with late pregnancy maternal methadone dosage. Neonatal seizures occurred in 1.5% of the heroin group and 10% of the methadone group. Discharge of an infant to a parent rather than to an alternate care-taker was more likely if the mother was enrolled in a methadone treatment program. Methadone maintenance programs appear to offer significant therapeutic benefits, balancing the untoward effects of the drug on the newborn infant.
S R Kandall; S Albin; L M Gartner; K S Lee; A Eidelman; J Lowinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  1     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1979-02-12     Completed Date:  1979-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-69     Citation Subset:  IM    
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MeSH Terms
Fetal Death / etiology
Fetus / physiology*
Heroin Dependence / complications,  physiopathology
Infant Mortality
Infant, Newborn*
Infant, Newborn, Diseases / etiology
Pregnancy Complications*
Substance Withdrawal Syndrome / etiology
Substance-Related Disorders* / complications
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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