Document Detail


The naphyrone story: The alpha or beta-naphthyl isomer?
MedLine Citation:
PMID:  20886463     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Naphyrone (naphthylpyrovalerone, O-2482) has been recently advertised for purchase on a number of websites. This compound has been viewed as a so-called 'legal high' and was classified as a controlled drug under the UK Misuse of Drugs Act 1971 in mid-July 2010. So far, naphyrone is commonly equated with 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one (β-naphyrone) but analytical characterization of two naphyrone samples revealed the existence of a novel isomer consistent with 1-naphthalen-1-yl-2-pyrrolidin-1-yl-pentan-1-one (α-naphyrone). Analyses of both α- and β-naphyrone were carried out using gas chromatography ion trap (EI/CI) mass spectrometry and 1D/2D nuclear magnetic resonance spectroscopy. This provides the first report of α-naphyrone in the scientific literature and the ability to differentiate it from the β-isomer should be of interest to forensic and clinical communities.
Authors:
Simon D Brandt; Robert C R Wootton; Giorgia De Paoli; Sally Freeman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug testing and analysis     Volume:  2     ISSN:  1942-7611     ISO Abbreviation:  Drug Test Anal     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101483449     Medline TA:  Drug Test Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  496-502     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Liverpool John Moores University, UK. s.brandt@ljmu.ac.uk
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