| The naphyrone story: The alpha or beta-naphthyl isomer? | |
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MedLine Citation:
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PMID: 20886463 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Naphyrone (naphthylpyrovalerone, O-2482) has been recently advertised for purchase on a number of websites. This compound has been viewed as a so-called 'legal high' and was classified as a controlled drug under the UK Misuse of Drugs Act 1971 in mid-July 2010. So far, naphyrone is commonly equated with 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one (β-naphyrone) but analytical characterization of two naphyrone samples revealed the existence of a novel isomer consistent with 1-naphthalen-1-yl-2-pyrrolidin-1-yl-pentan-1-one (α-naphyrone). Analyses of both α- and β-naphyrone were carried out using gas chromatography ion trap (EI/CI) mass spectrometry and 1D/2D nuclear magnetic resonance spectroscopy. This provides the first report of α-naphyrone in the scientific literature and the ability to differentiate it from the β-isomer should be of interest to forensic and clinical communities. |
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Authors:
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Simon D Brandt; Robert C R Wootton; Giorgia De Paoli; Sally Freeman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug testing and analysis Volume: 2 ISSN: 1942-7611 ISO Abbreviation: Drug Test Anal Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101483449 Medline TA: Drug Test Anal Country: England |
Other Details:
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Languages: eng Pagination: 496-502 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Liverpool John Moores University, UK. s.brandt@ljmu.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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