| nPCR assessment and IDPN treatment of malnutrition in pediatric hemodialysis patients. | |
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MedLine Citation:
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PMID: 12172769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Very few pediatric studies have monitored nutritional status using normalized protein catabolic rate (nPCR) or treating protein-energy malnutrition (PEM) with intradialytic parenteral nutrition (IDPN). The current study compares nPCR with serum albumin as a marker for nutritional status and examines the effectiveness of IDPN treatment in three malnourished adolescent patients receiving chronic hemodialysis in a pediatric dialysis unit. All patients demonstrated reversal of weight loss and initiation of weight gain within 6 weeks of IDPN initiation. Mean values of monthly percentage weight and percentage body mass index (BMI) change were significantly lower in the pre-IDPN era (-0.61+/-2.70 and -1.3+/-2.7) versus the IDPN treatment period (1.8+/-2.1 and 1.3+/-2.1) ( P<0.02). Two patients attained ideal body weight and IDPN was discontinued after 5 months. Patients required 150% recommended daily allowance to achieve weight and BMI gain. While mean monthly nPCR was significantly lower in the pre-IDPN period versus the IDPN period (1.05+/-0.36 versus 1.35+/-0.37, P<0.05), monthly serum albumin levels were no different before and after IDPN was initiated (3.7+/-0.8 versus 3.8+/-0.6). The current study demonstrates IDPN to be effective therapy for adolescent hemodialysis patients with PEM not correctable by enteral supplementation. nPCR was superior to serum albumin as a nutritional status marker in these malnourished pediatric patients receiving hemodialysis. |
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Authors:
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Stuart L Goldstein; Shannon Baronette; Tywanna Vital Gambrell; Helen Currier; Eileen D Brewer |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2002-06-21 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 17 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-12 Completed Date: 2003-02-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 531-4 Citation Subset: IM |
Affiliation:
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Renal Service, Texas Children's Hospital, 6621 Fannin Street, MC 3-2482, Houston 77030, USA. stuartg@bcm.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Nutritional Physiological Phenomena Adult Body Weight Humans Kidney Failure, Chronic / complications, therapy* Parenteral Nutrition / methods* Protein-Energy Malnutrition / diagnosis, etiology, therapy* Proteins / metabolism Renal Dialysis / methods* Sensitivity and Specificity Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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