Document Detail


Is a (n inborn) deficiency of prostacyclin synthesis stimulating plasma factor associated with increased lipoprotein(a)?
MedLine Citation:
PMID:  8981634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with the antiphospholipid syndrome as well as those with a lack in the prostacyclin synthesis stimulating plasma factor (PF) are prone to develop thrombophilia and are at a higher clinical risk for vascular disease. As patients with the antiphospholipid syndrome have been reported to show elevated lipoprotein (Lp)(a) levels, we re-examined all our patients known to have an inborn or an acquired persistent deficiency of PF. Their non-affected relatives served as controls. In addition, 36 patients suffering from clinically manifested atherosclerosis as well as 16 healthy adults, all of them having elevated Lp(a) levels (> 30 mg/dl), were screened for a PF deficiency. In fact, all the patients with a deficient PF activity showed elevated Lp(a) values. While the prevalence of PF deficiency ranges about 1-2%, in 7 (19%) patients with clinically manifested atherosclerosis and 3 (19%) healthy adults with elevated Lp(a) this defect was found. The findings demonstrate an association between PF deficiency and Lp(a), indicating a biochemical interaction which needs to be further elucidated.
Authors:
H Kritz; J Pidlich; J O'Grady; H Sinzinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  55     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-21     Completed Date:  1997-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  363-72     Citation Subset:  IM    
Affiliation:
Wilhelm-Auerswald Atherosclerosis Research Group (ASF), Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antithrombin III / analysis
Arteriosclerosis / genetics,  metabolism*
Biological Factors / blood,  deficiency*,  metabolism*
Case-Control Studies
Child
Female
Follow-Up Studies
Humans
Lipid Metabolism
Lipids / blood
Lipoprotein(a) / blood*
Male
Metabolism, Inborn Errors / genetics,  metabolism*
Middle Aged
Pedigree
Protein C / analysis
Protein S / analysis
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Lipids; 0/Lipoprotein(a); 0/Protein C; 0/Protein S; 0/prostacyclin synthesis stimulating plasma factor; 9000-94-6/Antithrombin III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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