Document Detail

n-Hexane metabolism in occupationally exposed workers.
MedLine Citation:
PMID:  6498115     Owner:  NLM     Status:  MEDLINE    
Lung uptake and excretion of n-hexane were studied in ten workers in a shoe factory. Simultaneous samples of inhaled and alveolar air were collected with the aid of a Rhan-Otis valve, personal samplers, and charcoal tubes. Alveolar excretion was monitored during a six hour postexposure period. Uptake was calculated from lung ventilation, the retention coefficient, and environmental concentrations. The amount of exhaled n-hexane was calculated from the decay curve. According to the experimental data, alveolar retention was about 25% of the inhaled n-hexane, corresponding to a lung uptake of about 17%. The postexposure alveolar excretion was about 10% of the total uptake. The main metabolites of n-hexane were identified and measured by capillary GC/MS in spot urine samples collected before, at the end, and 15 hours after the same working shift. Urinary concentrations were low, though related to n-hexane in the air. 2,5-Hexanedione in the end of shift samples gave the best estimate of overall exposure. About 3 mg/g creatinine of 2,5-hexanedione would correspond to about 50 ppm of n-hexane in the air (mean daily exposure).
A Mutti; M Falzoi; S Lucertini; G Arfini; M Zignani; S Lombardi; I Franchini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  41     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
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MeSH Terms
Environmental Exposure
Hexanes / metabolism*,  urine
Lung / metabolism
Occupational Medicine*
Pulmonary Alveoli / metabolism
Reg. No./Substance:
0/Hexanes; 110-54-3/n-hexane

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