Document Detail


n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations.
MedLine Citation:
PMID:  20522273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
n-6 PUFA are well known for their critical role in many physiological functions and seem to reduce risks of CHD. However, some argue that excessive consumption of n-6 PUFA may lead to adverse effects on health and therefore recommend reducing dietary n-6 PUFA intake or fixing an upper limit. In this context, the present work aimed to review evidence on the link between n-6 PUFA and risks of CVD. Epidemiological studies show that n-6 PUFA dietary intake significantly lowers blood LDL-cholesterol levels. In addition, n-6 PUFA intake does not increase several CVD risk factors such as blood pressure, inflammatory markers, haemostatic parameters and obesity. Data from prospective cohort and interventional studies converge towards a specific protective role of dietary n-6 PUFA intake, in particular linoleic acid, against CVD. n-6 PUFA benefits are even increased when SFA intake is also reduced. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5 %, and ideally about 10 %, of total energy appears justified.
Authors:
Sébastien Czernichow; Daniel Thomas; Eric Bruckert
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-04
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  788-96     Citation Subset:  IM    
Affiliation:
Nutritional Epidemiology Research Unit, UMR INSERM U557, INRA U1125, CNAM, UP13, CRNH-IdF, Faculté SMBH, 74 rue Marcel Cachin, 93017 Bobigny, France. s.czernichow@uren.smbh.univ-paris13.fr
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / prevention & control*
Dietary Fats / administration & dosage*
Fatty Acids / administration & dosage
Fatty Acids, Omega-6 / administration & dosage,  adverse effects,  therapeutic use*
Humans
Linoleic Acid / therapeutic use
Nutrition Policy*
Risk Factors
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-6; 2197-37-7/Linoleic Acid

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