Document Detail


n-3 fatty acids only delay early relapse of ulcerative colitis in remission.
MedLine Citation:
PMID:  8888725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Relapse prevention by dietary n-3 fatty acids (5.1 g/day) was studied in a double-blind, placebo-controlled trial of 64 patients with ulcerative colitis in remission and off steroids. 5-ASA compounds were stopped three months after randomization and clinical disease activity monitored for two years. Macroscopic and histologic activity and extension was assessed by colonoscopy at entry and at exit. Both treatment groups were well matched at start. Nine patients on placebo and eight on n-3 fatty acids stopped taking their medication prematurely. Actuarial relapse-free survival was improved by n-3 fatty acids only during months 2 and 3 (2P < 0.05-0.01), but cumulative relapse rate at two years was similar for those taking placebo (18/33 = 55%) and n-3 fatty acids (18/31 = 58%). There was also no consistent difference in clinical, macroscopic, and histologic disease activity between treatment groups. The n-3 fatty acids temporarily retard, but do not prevent, relapse of ulcerative colitis.
Authors:
K Loeschke; B Ueberschaer; A Pietsch; E Gruber; K Ewe; B Wiebecke; W Heldwein; R Lorenz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  41     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2087-94     Citation Subset:  AIM; IM    
Affiliation:
Klinikum Innenstadt, Universität München, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actuarial Analysis
Adult
Colitis, Ulcerative / physiopathology,  prevention & control*
Double-Blind Method
Fatty Acids, Omega-3 / administration & dosage*,  adverse effects
Female
Humans
Male
Prospective Studies
Recurrence
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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