| n-3 fatty acids as precursors for active metabolic substances: dissonance between expected and observed events. | |
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MedLine Citation:
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PMID: 2539828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It may be hypothesized that many diseases are associated with an overproduction of eicosanoids from the n-6 acid, arachidonic acid (20:4n-6), and the formation and function of these n-6 eicosanoids can be antagonized by dietary n-3 fats. This hypothesis provides a basis for evaluating the benefits and risks of including various amounts of n-3 and n-6 fats in the diet. Understanding the impact of dietary polyunsaturated fats leads inevitably to a reappraisal of what is 'normal' in terms of what is typical and what is desirable for the fatty acid composition of tissue lipids, the magnitude of eicosanoid-mediated responses, and the frequency and severity of certain diseases. |
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Authors:
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W E Lands |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of internal medicine. Supplement Volume: 731 ISSN: 0955-7873 ISO Abbreviation: J Intern Med Suppl Publication Date: 1989 |
Date Detail:
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Created Date: 1989-06-02 Completed Date: 1989-06-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8912975 Medline TA: J Intern Med Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Illinois, Chicago. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / prevention & control Dietary Fats, Unsaturated / pharmacology Docosahexaenoic Acids / administration & dosage, metabolism* Dose-Response Relationship, Drug Eicosanoic Acids / biosynthesis Eicosapentaenoic Acid / administration & dosage, metabolism* Fatty Acids, Nonesterified / metabolism Humans Liver / metabolism Lung / metabolism Phospholipids / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Eicosanoic Acids; 0/Fatty Acids, Nonesterified; 0/Phospholipids; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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