Document Detail


(n-3) fatty acid supplementation in moderately hypertriglyceridemic adults changes postprandial lipid and apolipoprotein B responses to a standardized test meal.
MedLine Citation:
PMID:  10356076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of (n-3) fatty acids on the postprandial state were investigated by monitoring the alimentary responses to identical test meals fed to adults [n = 11; fasting triacylglycerol (TG) 2.55 +/- 0.24 mmol/L; mean +/- SEM] after a self-selected diet baseline period (BLP) and then after a 6-wk (n-3) fatty acid period (FOP) [ approximately 5.2 g (n-3) fatty acids] and a 6-wk control oil period (COP) administered in random order. Samples were drawn immediately prior to the test meal (time 0) and then hourly from 2 to 6 h postmeal. Postprandial plasma triacylglycerol (TG) and TG-rich lipoprotein (TRL) TG apo B48, and B100 absolute concentrations were significantly lower after FOP than after COP or BLP, while plasma cholesterol was unchanged. Normalizing the results as increments over time 0 eliminated the diet effect on all but plasma TG. Time remained a significant effect for plasma TG, TRL TG, and TRL TC. Finally, only absolute TRL B48 and absolute and incremental plasma TG concentrations displayed significant time-diet interactions. These results suggest that postprandial TRL apo B reductions are likely caused by (n-3) fatty acid suppression of both hepatic and intestinal apoB secretion/synthesis. Altered TRL metabolism, i.e. changes in postprandial TG, cholesterol, apo B48, and increase in LDL particle size, may represent an additional mechanism for the reduced heart disease risk associated with fish [(n-3) fatty acid] consumption.
Authors:
L F Tinker; E J Parks; S R Behr; B O Schneeman; P A Davis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  129     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1126-34     Citation Subset:  IM    
Affiliation:
Division of Clinical Nutrition and Metabolism, Department of Internal Medicine, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoproteins B / blood*
Cross-Over Studies
Dietary Supplements*
Eating / physiology*
Fasting
Fatty Acids, Omega-3 / therapeutic use*
Female
Humans
Hypertriglyceridemia / blood*
Lipids / blood*
Male
Middle Aged
Time Factors
Grant Support
ID/Acronym/Agency:
DK 35747/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins B; 0/Fatty Acids, Omega-3; 0/Lipids

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